Bat-to-human: spike features determining ‘host jump’ of coronaviruses SARS-CoV, MERS-CoV, and beyond
Identifieur interne : 001360 ( Main/Exploration ); précédent : 001359; suivant : 001361Bat-to-human: spike features determining ‘host jump’ of coronaviruses SARS-CoV, MERS-CoV, and beyond
Auteurs : Guangwen Lu [République populaire de Chine] ; Qihui Wang [République populaire de Chine] ; George F. Gao [République populaire de Chine]Source :
- Trends in Microbiology [ 0966-842X ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Chiroptera, Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie), Glycoprotéine de spicule des coronavirus (génétique), Glycoprotéine de spicule des coronavirus (métabolisme), Humains, Infections à coronavirus (médecine vétérinaire), Infections à coronavirus (transmission), Liaison aux protéines, Pénétration virale, Spécificité d'hôte, Tropisme viral, Virus du SRAS (génétique), Virus du SRAS (physiologie), Zoonoses (transmission).
- MESH :
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient, Glycoprotéine de spicule des coronavirus, Virus du SRAS.
- médecine vétérinaire : Infections à coronavirus.
- métabolisme : Glycoprotéine de spicule des coronavirus.
- physiologie : Coronavirus du syndrome respiratoire du Moyen-Orient, Virus du SRAS.
- transmission : Animaux, Chiroptera, Humains, Infections à coronavirus, Liaison aux protéines, Pénétration virale, Spécificité d'hôte, Tropisme viral, Zoonoses.
English descriptors
- KwdEn :
- Animals, Chiroptera, Coronavirus Infections (transmission), Coronavirus Infections (veterinary), Host Specificity, Humans, Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (physiology), Protein Binding, SARS Virus (genetics), SARS Virus (physiology), Spike Glycoprotein, Coronavirus (genetics), Spike Glycoprotein, Coronavirus (metabolism), Viral Tropism, Virus Internalization, Zoonoses (transmission).
- MESH :
- chemical , genetics : Spike Glycoprotein, Coronavirus.
- genetics : Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- chemical , metabolism : Spike Glycoprotein, Coronavirus.
- physiology : Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- transmission : Coronavirus Infections, Zoonoses.
- veterinary : Coronavirus Infections.
- Animals, Chiroptera, Host Specificity, Humans, Protein Binding, Viral Tropism, Virus Internalization.
Abstract
Bats are natural reservoirs of many coronaviruses that can infect humans. Mechanisms of cross-species transmission of coronaviruses are important scientific questions. The coronaviral spike protein is an important viral determinant of cross-species transmission. Receptor-binding characteristics and cleavage priming of the spike protein are summarized.
Url:
DOI: 10.1016/j.tim.2015.06.003
PubMed: 26206723
PubMed Central: 7125587
Affiliations:
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<front><div type="abstract" xml:lang="en"><title>Highlights</title>
<p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label>
<p id="par0005">Bats are natural reservoirs of many coronaviruses that can infect humans.</p>
</list-item>
<list-item id="lsti0010"><label>•</label>
<p id="par0010">Mechanisms of cross-species transmission of coronaviruses are important scientific questions.</p>
</list-item>
<list-item id="lsti0015"><label>•</label>
<p id="par0015">The coronaviral spike protein is an important viral determinant of cross-species transmission.</p>
</list-item>
<list-item id="lsti0020"><label>•</label>
<p id="par0020">Receptor-binding characteristics and cleavage priming of the spike protein are summarized.</p>
</list-item>
</list>
</p>
</div>
</front>
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</back>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
<settlement><li>Pékin</li>
</settlement>
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<tree><country name="République populaire de Chine"><noRegion><name sortKey="Lu, Guangwen" sort="Lu, Guangwen" uniqKey="Lu G" first="Guangwen" last="Lu">Guangwen Lu</name>
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<name sortKey="Gao, George F" sort="Gao, George F" uniqKey="Gao G" first="George F." last="Gao">George F. Gao</name>
<name sortKey="Gao, George F" sort="Gao, George F" uniqKey="Gao G" first="George F." last="Gao">George F. Gao</name>
<name sortKey="Lu, Guangwen" sort="Lu, Guangwen" uniqKey="Lu G" first="Guangwen" last="Lu">Guangwen Lu</name>
<name sortKey="Wang, Qihui" sort="Wang, Qihui" uniqKey="Wang Q" first="Qihui" last="Wang">Qihui Wang</name>
<name sortKey="Wang, Qihui" sort="Wang, Qihui" uniqKey="Wang Q" first="Qihui" last="Wang">Qihui Wang</name>
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